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Soft Substrates Containing Hyaluronan Mimic the Effects of Increased Stiffness on Morphology, Motility, and Proliferation of Glioma Cells

Unlike many other cancer cells that grow in tumors characterized by an abnormally stiff collagen-enriched stroma, glioma cells proliferate and migrate in the much softer environment of the brain, which generally lacks the filamentous protein matrix characteristic of breast, liver, colorectal, and ot...

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Bibliographic Details
Published in:Biomacromolecules
Main Authors: Pogoda, Katarzyna, Bucki, Robert, Byfield, Fitzroy J., Cruz, Katrina, Lee, Tongkeun, Marcinkiewicz, Cezary, Janmey, Paul A.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063754/
https://ncbi.nlm.nih.gov/pubmed/28858529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biomac.7b00324
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