Dual-requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Myelin Repair

Disruptive mutations in chromatin remodeler CHD8 cause autism spectrum disorders, exhibiting widespread white matter abnormalities; however, the underlying mechanisms remain elusive. We show that cell-type specific Chd8 deletion in oligodendrocyte progenitors, but not in neurons, results in myelinat...

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Bibliographic Details
Published in:Dev Cell
Main Authors: Zhao, Chuntao, Dong, Chen, Frah, Magali, Deng, Yaqi, Marie, Corentine, Zhang, Feng, Xu, Lingli, Ma, Zhixing, Dong, Xinran, Lin, Yifeng, Koenig, Scott, Nait-Oumesmar, Brahim, Martin, Donna M., Wu, Laiman N., Xin, Mei, Zhou, Wenhao, Parras, Carlos, Lu, Q. Richard
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063525/
https://ncbi.nlm.nih.gov/pubmed/29920279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.05.022
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