Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome

Clarin-1, a tetraspan-like membrane protein defective in Usher syndrome type IIIA (USH3A), is essential for hair bundle morphogenesis in auditory hair cells. We report a new synaptic role for clarin-1 in mouse auditory hair cells elucidated by characterization of Clrn1 total (Clrn1(ex4–/–)) and post...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Clin Invest
Hlavní autoři: Dulon, Didier, Papal, Samantha, Patni, Pranav, Cortese, Matteo, Vincent, Philippe F.Y., Tertrais, Margot, Emptoz, Alice, Tlili, Abdelaziz, Bouleau, Yohan, Michel, Vincent, Delmaghani, Sedigheh, Aghaie, Alain, Pepermans, Elise, Alegria-Prevot, Olinda, Akil, Omar, Lustig, Lawrence, Avan, Paul, Safieddine, Saaid, Petit, Christine, El-Amraoui, Aziz
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063508/
https://ncbi.nlm.nih.gov/pubmed/29985171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94351
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky