TNF overproduction impairs epithelial staphylococcal response in hyper IgE syndrome

Autosomal dominant hyper IgE syndrome (AD-HIES), or Job’s syndrome, is a primary immune deficiency caused by dominant-negative mutations in STAT3. Recurrent Staphylococcus aureus skin abscesses are a defining feature of this syndrome. A widely held hypothesis that defects in peripheral Th17 differen...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Myles, Ian A., Anderson, Erik D., Earland, Noah J., Zarember, Kol A., Sastalla, Inka, Williams, Kelli W., Gough, Portia, Moore, Ian N., Ganesan, Sundar, Fowler, Cedar J., Laurence, Arian, Garofalo, Mary, Kuhns, Douglas B., Kieh, Mark D., Saleem, Arhum, Welch, Pamela A., Darnell, Dirk A., Gallin, John I., Freeman, Alexandra F., Holland, Steven M., Datta, Sandip K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063472/
https://ncbi.nlm.nih.gov/pubmed/30035749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121486
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