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Eupatilin rescues ciliary transition zone defects to ameliorate ciliopathy-related phenotypes
Ciliopathies are clinically overlapping genetic disorders involving structural and functional abnormalities of cilia. Currently, there are no small-molecule drugs available to treat ciliary defects in ciliopathies. Our phenotype-based screen identified the flavonoid eupatilin and its analogs as lead...
Shranjeno v:
| izdano v: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Clinical Investigation
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6063470/ https://ncbi.nlm.nih.gov/pubmed/30035750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99232 |
| Oznake: |
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