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Vrk1 partial Knockdown in Mice Results in Reduced Brain Weight and Mild Motor Dysfunction, and Indicates Neuronal VRK1 Target Pathways

Mutations in Vaccinia-related kinase 1 (VRK1) have emerged as a cause of severe neuronal phenotypes in human, including brain developmental defects and degeneration of spinal motor neurons, leading to Spinal Muscular Atrophy (SMA) or early onset Amyotrophic Lateral Sclerosis (ALS). Vrk1 gene-trap pa...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Vinograd-Byk, Hadar, Renbaum, Paul, Levy-Lahad, Ephrat
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062608/
https://ncbi.nlm.nih.gov/pubmed/30050127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29215-x
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