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Pyrazinamide-induced hepatotoxicity and gender differences in rats as revealed by a (1)H NMR based metabolomics approach
Pyrazinamide (PZA) is a well-known first line anti-tuberculosis drug used in combination with other drugs such as isoniazid and rifampicin. Unfortunately, PZA suffered from a high rate of hepatotoxicity and hyperuricemia, which has not been clearly elucidated, hindering its wide application for ther...
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| Publicat a: | Toxicol Res (Camb) |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Royal Society of Chemistry
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6062402/ https://ncbi.nlm.nih.gov/pubmed/30090474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6tx00245e |
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