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Mapping the in vivo fitness landscape of lung adenocarcinoma tumor suppression in mice
The functional impact of most genomic alterations found in cancer, alone or in combination, remains largely unknown. Here we integrate tumor barcoding, CRISPR/Cas9-mediated genome editing and ultra-deep barcode sequencing to interrogate pairwise combinations of tumor suppressor alterations in autoch...
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| Publicat a: | Nat Genet |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6061949/ https://ncbi.nlm.nih.gov/pubmed/29610476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0083-2 |
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