An Integrated Genome Wide CRISPRa Approach to Functionalize IncRNAs in Drug Resistance

Resistance to chemotherapy plays a significant role in cancer mortality. To identify genetic units affecting sensitivity to cytarabine, the mainstay of treatment for AML, we developed a comprehensive and integrated genome wide platform based on a Dual protein-coding and noncoding Integrated CRISPRa...

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Gepubliceerd in:Cell
Hoofdauteurs: Bester, Assaf C., Lee, Jonathan D., Chavez, Alejandro, Lee, Yu-Ru, Nachmani, Daphna, Vora, Su, Victor, Joshua, Sauvageau, Martin, Rinn, John L., Provero, Paolo, Church, George M., Clohessy, John G., Pandolfi, Pier Paolo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061940/
https://ncbi.nlm.nih.gov/pubmed/29677511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.052
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