Withdrawal of caffeine after its chronic administration modifies the antidepressant-like activity of atypical antidepressants in mice. Changes in cortical expression of Comt, Slc6a15 and Adora1 genes

RATIONALE: Depressed patients often present increased consumption of caffeine. OBJECTIVES: We aimed to investigate the effects of chronic treatment with caffeine (5 mg/kg, twice daily for 14 days) on the activity of single, ineffective doses of agomelatine (20 mg/kg) or mianserin (10 mg/kg) given on...

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Detalhes bibliográficos
Publicado no:Psychopharmacology (Berl)
Main Authors: Szopa, Aleksandra, Poleszak, Ewa, Doboszewska, Urszula, Herbet, Mariola, Świąder, Katarzyna, Wyska, Elżbieta, Serefko, Anna, Wlaź, Aleksandra, Korga, Agnieszka, Ostrowska, Marta, Juś, Piotr, Jedynak, Szymon, Dudka, Jarosław, Wlaź, Piotr
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2018
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061707/
https://ncbi.nlm.nih.gov/pubmed/29882086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-018-4940-6
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