NADP(+)-dependent cytosolic isocitrate dehydrogenase provides NADPH in the presence of cadmium due to the moderate chelating effect of glutathione

Cadmium (Cd(2+)) is toxic to living organisms because it causes the malfunction of essential proteins and induces oxidative stress. NADP(+)-dependent cytosolic isocitrate dehydrogenase (IDH) provides reducing energy to counteract oxidative stress via oxidative decarboxylation of isocitrate. Intrigui...

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Veröffentlicht in:J Biol Inorg Chem
Hauptverfasser: Cho, Hyo Je, Cho, Ha Yeon, Park, Jeen-Woo, Kwon, Oh-Shin, Lee, Hyun-Shik, Huh, Tae Lin, Kang, Beom Sik
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2018
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6060952/
https://ncbi.nlm.nih.gov/pubmed/29923039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-018-1581-5
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