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Distinct Phenotypes of Shank2 Mouse Models Reflect Neuropsychiatric Spectrum Disorders of Human Patients With SHANK2 Variants

The SHANK scaffolding proteins are important organizers for signaling proteins in the postsynapse of excitatory neurons. The functional significance of SHANK proteins becomes apparent by the wide spectrum of neurodevelopmental and neuropsychiatric disorders associated with SHANK variants in human pa...

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Udgivet i:Front Mol Neurosci
Main Authors: Eltokhi, Ahmed, Rappold, Gudrun, Sprengel, Rolf
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6060255/
https://ncbi.nlm.nih.gov/pubmed/30072871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00240
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