Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance

Islet transplantation is a promising therapy for type 1 diabetes. However, chronic immunosuppression to control rejection of allogeneic islets induces morbidities and impairs islet function. T-effector cells are responsible for islet allograft rejection and express Fas death receptor following activ...

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Publicado en:Nat Mater
Main Authors: Headen, Devon M., Woodward, Kyle B., Coronel, María M., Shrestha, Pradeep, Weaver, Jessica D., Zhao, Hong, Tan, Min, Hunckler, Michael D., Bowen, William S., Johnson, Christopher T., Shea, Lonnie, Yolcu, Esma S., García, Andrés J., Shirwan, Haval
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6060019/
https://ncbi.nlm.nih.gov/pubmed/29867165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41563-018-0099-0
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