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Discovery of fragments that target key interactions in the signal recognition particle (SRP) as potential leads for a new class of antibiotics

Given the increasing incidence of antibiotic resistance, antibiotics that employ new strategies are urgently needed. Bacterial survival is dependent on proper function of the signal recognition particle (SRP) and its receptor (FtsY). A unique set of interactions in FtsY:SRP-RNA represents a promisin...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Faoro, Camilla, Wilkinson-White, Lorna, Kwan, Ann H., Ataide, Sandro F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6059433/
https://ncbi.nlm.nih.gov/pubmed/30044812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200387
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