Gastroretentive raft liquid delivery system as a new approach to release extension for carrier-mediated drug

Gabapentin (GBP), an antiepileptic and anti-neuropathic agent, suffers from short half-life (5–7 h), has narrow absorption window, and is absorbed via carrier-mediated mechanism resulting in frequent dosing, poor compliance, and poor bioavailability (<60%). Moreover, GBP is a freely water-soluble...

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Bibliografiske detaljer
Udgivet i:Drug Deliv
Main Authors: Abouelatta, Samar M., Aboelwafa, Ahmed A., El-Gazayerly, Omaima N.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058684/
https://ncbi.nlm.nih.gov/pubmed/29792353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2018.1474969
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