Structural Lipids Enable the Formation of Functional Oligomers of the Eukaryotic Purine Symporter UapA

The role of membrane lipids in modulating eukaryotic transporter assembly and function remains unclear. We investigated the effect of membrane lipids in the structure and transport activity of the purine transporter UapA from Aspergillus nidulans. We found that UapA exists mainly as a dimer and that...

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Pubblicato in:Cell Chem Biol
Autori principali: Pyle, Euan, Kalli, Antreas C., Amillis, Sotiris, Hall, Zoe, Lau, Andy M., Hanyaloglu, Aylin C., Diallinas, George, Byrne, Bernadette, Politis, Argyris
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058078/
https://ncbi.nlm.nih.gov/pubmed/29681524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.03.011
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