Structural Lipids Enable the Formation of Functional Oligomers of the Eukaryotic Purine Symporter UapA

The role of membrane lipids in modulating eukaryotic transporter assembly and function remains unclear. We investigated the effect of membrane lipids in the structure and transport activity of the purine transporter UapA from Aspergillus nidulans. We found that UapA exists mainly as a dimer and that...

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Vydáno v:Cell Chem Biol
Hlavní autoři: Pyle, Euan, Kalli, Antreas C., Amillis, Sotiris, Hall, Zoe, Lau, Andy M., Hanyaloglu, Aylin C., Diallinas, George, Byrne, Bernadette, Politis, Argyris
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058078/
https://ncbi.nlm.nih.gov/pubmed/29681524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.03.011
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