Structural Lipids Enable the Formation of Functional Oligomers of the Eukaryotic Purine Symporter UapA

The role of membrane lipids in modulating eukaryotic transporter assembly and function remains unclear. We investigated the effect of membrane lipids in the structure and transport activity of the purine transporter UapA from Aspergillus nidulans. We found that UapA exists mainly as a dimer and that...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Pyle, Euan, Kalli, Antreas C., Amillis, Sotiris, Hall, Zoe, Lau, Andy M., Hanyaloglu, Aylin C., Diallinas, George, Byrne, Bernadette, Politis, Argyris
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058078/
https://ncbi.nlm.nih.gov/pubmed/29681524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.03.011
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