Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer

The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms can...

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Udgivet i:Nat Commun
Main Authors: Cazet, Aurélie S., Hui, Mun N., Elsworth, Benjamin L., Wu, Sunny Z., Roden, Daniel, Chan, Chia-Ling, Skhinas, Joanna N., Collot, Raphaël, Yang, Jessica, Harvey, Kate, Johan, M. Zahied, Cooper, Caroline, Nair, Radhika, Herrmann, David, McFarland, Andrea, Deng, Niantao, Ruiz-Borrego, Manuel, Rojo, Federico, Trigo, José M., Bezares, Susana, Caballero, Rosalía, Lim, Elgene, Timpson, Paul, O’Toole, Sandra, Watkins, D. Neil, Cox, Thomas R., Samuel, Michael S., Martín, Miguel, Swarbrick, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057940/
https://ncbi.nlm.nih.gov/pubmed/30042390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05220-6
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