Incorporation of NS1 and prM/M are important to confer effective protection of adenovirus-vectored Zika virus vaccine carrying E protein

Current design of Zika virus (ZIKV) vaccine mainly considered envelope (E) as the major target antigen. Non-structural protein NS1 was seldom considered. Herein, we generated three adenovirus-vectored vaccines carrying E (Ad2-E), or premembrane/membrane (prM/M) with E (Ad2-prME), or NS1 in addition...

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Detalhes bibliográficos
Publicado no:NPJ Vaccines
Main Authors: Liu, Xinglong, Qu, Linbing, Ye, Xianmiao, Yi, Changhua, Zheng, Xuehua, Hao, Mingli, Su, Wan, Yao, Zhipeng, Chen, Peihai, Zhang, Shengnan, Feng, Yupeng, Wang, Qian, Yan, Qihong, Li, Pingchao, Li, Heying, Li, Feng, Pan, Weiqi, Niu, Xuefeng, Xu, Ruian, Feng, Liqiang, Chen, Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057874/
https://ncbi.nlm.nih.gov/pubmed/30062066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-018-0072-6
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