Effect of TP53 contact and conformational mutations on cell survival and erythropoiesis of human hematopoietic stem cells in a long term culture model

TP53 deficiencies characterize myeloid malignancies with a dismal prognosis. To unravel the pathomechanism of TP53 mutations in the development of myeloid malignancies, we analyzed the functional properties of TP53 conformational and contact mutations and TP53 loss in human CD34+ cells. We show for...

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發表在:Oncotarget
Main Authors: Salari, Azam, Thomay, Kathrin, Lentes, Jana, Ebersold, Juliane, Hagedorn, Maike, Skawran, Britta, Davenport, Claudia, Schambach, Axel, Schlegelberger, Brigitte, Göhring, Gudrun
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2018
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057451/
https://ncbi.nlm.nih.gov/pubmed/30042819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25581
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