Effect of TP53 contact and conformational mutations on cell survival and erythropoiesis of human hematopoietic stem cells in a long term culture model

TP53 deficiencies characterize myeloid malignancies with a dismal prognosis. To unravel the pathomechanism of TP53 mutations in the development of myeloid malignancies, we analyzed the functional properties of TP53 conformational and contact mutations and TP53 loss in human CD34+ cells. We show for...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Salari, Azam, Thomay, Kathrin, Lentes, Jana, Ebersold, Juliane, Hagedorn, Maike, Skawran, Britta, Davenport, Claudia, Schambach, Axel, Schlegelberger, Brigitte, Göhring, Gudrun
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057451/
https://ncbi.nlm.nih.gov/pubmed/30042819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25581
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