Effect of TP53 contact and conformational mutations on cell survival and erythropoiesis of human hematopoietic stem cells in a long term culture model

TP53 deficiencies characterize myeloid malignancies with a dismal prognosis. To unravel the pathomechanism of TP53 mutations in the development of myeloid malignancies, we analyzed the functional properties of TP53 conformational and contact mutations and TP53 loss in human CD34+ cells. We show for...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Salari, Azam, Thomay, Kathrin, Lentes, Jana, Ebersold, Juliane, Hagedorn, Maike, Skawran, Britta, Davenport, Claudia, Schambach, Axel, Schlegelberger, Brigitte, Göhring, Gudrun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057451/
https://ncbi.nlm.nih.gov/pubmed/30042819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25581
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