Everolimus Plus Ku0063794 Regimen Promotes Anticancer Effects against Hepatocellular Carcinoma Cells through the Paradoxical Inhibition of Autophagy

PURPOSE: Everolimus only inhibits mammalian target of rapamycin complex 1 (mTORC1), whereas Ku0063794 inhibits both mTORC1 and mTORC2. Although they have similar anticancer effects, their combination has a synergistic effect against hepatocellular carcinoma (HCC) cells. We aimed to determine the mec...

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Bibliografiske detaljer
Udgivet i:Cancer Res Treat
Main Authors: Lee, Sang Chul, Kim, Kee-Hwan, Kim, Ok-Hee, Lee, Sang Kuon, Hong, Ha-Eun, Choi, Byung Jo, Jeong, Wonjun, Kim, Say-June
Format: Artigo
Sprog:Inglês
Udgivet: Korean Cancer Association 2018
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056969/
https://ncbi.nlm.nih.gov/pubmed/29121714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4143/crt.2017.085
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