A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer

Advanced colorectal cancer harbors extensive intratumor heterogeneity shaped by neutral evolution; however, intratumor heterogeneity in colorectal precancerous lesions has been poorly studied. We perform multiregion whole-exome sequencing on ten early colorectal tumors, which contained adenoma and c...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Saito, Tomoko, Niida, Atsushi, Uchi, Ryutaro, Hirata, Hidenari, Komatsu, Hisateru, Sakimura, Shotaro, Hayashi, Shuto, Nambara, Sho, Kuroda, Yosuke, Ito, Shuhei, Eguchi, Hidetoshi, Masuda, Takaaki, Sugimachi, Keishi, Tobo, Taro, Nishida, Haruto, Daa, Tsutomu, Chiba, Kenichi, Shiraishi, Yuichi, Yoshizato, Tetsuichi, Kodama, Masaaki, Okimoto, Tadayoshi, Mizukami, Kazuhiro, Ogawa, Ryo, Okamoto, Kazuhisa, Shuto, Mitsutaka, Fukuda, Kensuke, Matsui, Yusuke, Shimamura, Teppei, Hasegawa, Takanori, Doki, Yuichiro, Nagayama, Satoshi, Yamada, Kazutaka, Kato, Mamoru, Shibata, Tatsuhiro, Mori, Masaki, Aburatani, Hiroyuki, Murakami, Kazunari, Suzuki, Yutaka, Ogawa, Seishi, Miyano, Satoru, Mimori, Koshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056524/
https://ncbi.nlm.nih.gov/pubmed/30038269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05226-0
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