A novel calix[4]pyrrole derivative as a potential anticancer agent that forms genotoxic adducts with DNA

meso-(p-acetamidophenyl)-calix[4]pyrrole 3 was found to exhibit remarkable cytotoxicity towards A549 cancer cells. A comparative study including the isomer of 3 meso-(m-acetamidophenyl)-calix[4]pyrrole 5, as well as molecules containing ‘fragments’ of these structures, demonstrated that both the cal...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Geretto, Marta, Ponassi, Marco, Casale, Martina, Pulliero, Alessandra, Cafeo, Grazia, Malagreca, Ferdinando, Profumo, Aldo, Balza, Enrica, Bersimbaev, Rakhmetkazhi, Kohnke, Franz Heinrich, Rosano, Camillo, Izzotti, Alberto
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056420/
https://ncbi.nlm.nih.gov/pubmed/30038406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29314-9
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