Widespread epigenomic, transcriptomic and proteomic differences between hip osteophytic and articular chondrocytes in osteoarthritis

OBJECTIVES: To identify molecular differences between chondrocytes from osteophytic and articular cartilage tissue from OA patients. METHODS: We investigated genes and pathways by combining genome-wide DNA methylation, RNA sequencing and quantitative proteomics in isolated primary chondrocytes from...

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Vydáno v:Rheumatology (Oxford)
Hlavní autoři: Steinberg, Julia, Brooks, Roger A, Southam, Lorraine, Bhatnagar, Sahir, Roumeliotis, Theodoros I, Hatzikotoulas, Konstantinos, Zengini, Eleni, Wilkinson, J Mark, Choudhary, Jyoti S, McCaskie, Andrew W, Zeggini, Eleftheria
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Basic and Translational Science
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055583/
https://ncbi.nlm.nih.gov/pubmed/29741735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/key101
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