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Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability

BACKGROUND: Antioxidant enzymes play a fundamental role in counteracting oxidative stress induced by high glucose. Although mitochondrial superoxide dismutase (SOD2) is the principal defence against the toxicity of superoxide anions, the mechanism of its inactivation in diabetic subjects is still po...

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Detalhes bibliográficos
Publicado no:Cardiovasc Diabetol
Main Authors: La Sala, Lucia, Mrakic-Sposta, Simona, Micheloni, Stefano, Prattichizzo, Francesco, Ceriello, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055345/
https://ncbi.nlm.nih.gov/pubmed/30037352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-018-0748-2
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