Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability

BACKGROUND: Antioxidant enzymes play a fundamental role in counteracting oxidative stress induced by high glucose. Although mitochondrial superoxide dismutase (SOD2) is the principal defence against the toxicity of superoxide anions, the mechanism of its inactivation in diabetic subjects is still po...

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Detaylı Bibliyografya
Yayımlandı:Cardiovasc Diabetol
Asıl Yazarlar: La Sala, Lucia, Mrakic-Sposta, Simona, Micheloni, Stefano, Prattichizzo, Francesco, Ceriello, Antonio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2018
Konular:
Original Investigation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055345/
https://ncbi.nlm.nih.gov/pubmed/30037352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-018-0748-2
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