Interleukin-35 Inhibits TNF-α-Induced Osteoclastogenesis and Promotes Apoptosis via Shifting the Activation From TNF Receptor-Associated Death Domain (TRADD)–TRAF2 to TRADD–Fas-Associated Death Domain by JAK1/STAT1

Over-activated osteoclasts derived from myeloid or peripheral blood monocytes by inflammatory cytokines results in osteoporosis, osteoarthritis, and other bone erosion-related diseases. Interleukin 35 (IL-35) is a novel anti-inflammatory and immunosuppressive factor. This study investigated the effe...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Peng, Mingzheng, Wang, Yanguo, Qiang, Lei, Xu, Yan, Li, Cuidi, Li, Tao, Zhou, Xiaojun, Xiao, Ming, Wang, Jinwu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054960/
https://ncbi.nlm.nih.gov/pubmed/30061878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01417
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