Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection and Neurobehavioral Recovery after Experimental Ischemic Stroke

Docosahexaenoic acid (DHA) and Neuroprotectin D1 (NPD1) are neuroprotective after experimental ischemic stroke. To explore underlying mechanisms, SD rats underwent 2h of middle cerebral artery occlusion (MCAo) and treated with DHA (5mg/kg, IV) or NPD1 (5μg/per rat, ICV) and vehicles 1h after. Neuro-...

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Publicado en:Mol Neurobiol
Main Authors: Belayev, Ludmila, Hong, Sung-Ha, Menghani, Hemant, Marcell, Shawn J, Obenaus, Andre, Freitas, Raul S, Khoutorova, Larissa, Balaszczuk, Veronica, Jun, Bokkyoo, Oriá, Reinaldo B, Bazan, Nicolas G.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054805/
https://ncbi.nlm.nih.gov/pubmed/29858774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1136-3
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