Up-Regulation of PI 3-Kinases and the Activation of PI3K-Akt Signaling Pathway in Cancer Stem-Like Cells Through DNA Hypomethylation Mediated by the Cancer Microenvironment

Previously, we have succeeded in converting induced pluripotent stem cells (iPSCs) into cancer stem cells (CSCs) by treating the iPSCs with conditioned medium of Lewis lung carcinoma (LLC) cells. The converted CSCs, named miPS-LLCcm cells, exhibited the self-renewal, differentiation potential, and p...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Oo, Aung Ko Ko, Calle, Anna Sanchez, Nair, Neha, Mahmud, Hafizah, Vaidyanath, Arun, Yamauchi, Junya, Khayrani, Aprilliana Cahya, Du, Juan, Alam, Md Jahangir, Seno, Akimasa, Mizutani, Akifumi, Murakami, Hiroshi, Iwasaki, Yoshiaki, Chen, Ling, Kasai, Tomonari, Seno, Masaharu
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2018
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054593/
https://ncbi.nlm.nih.gov/pubmed/29621663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2018.03.001
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