Up-Regulation of PI 3-Kinases and the Activation of PI3K-Akt Signaling Pathway in Cancer Stem-Like Cells Through DNA Hypomethylation Mediated by the Cancer Microenvironment

Previously, we have succeeded in converting induced pluripotent stem cells (iPSCs) into cancer stem cells (CSCs) by treating the iPSCs with conditioned medium of Lewis lung carcinoma (LLC) cells. The converted CSCs, named miPS-LLCcm cells, exhibited the self-renewal, differentiation potential, and p...

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Bibliografiske detaljer
Udgivet i:Transl Oncol
Main Authors: Oo, Aung Ko Ko, Calle, Anna Sanchez, Nair, Neha, Mahmud, Hafizah, Vaidyanath, Arun, Yamauchi, Junya, Khayrani, Aprilliana Cahya, Du, Juan, Alam, Md Jahangir, Seno, Akimasa, Mizutani, Akifumi, Murakami, Hiroshi, Iwasaki, Yoshiaki, Chen, Ling, Kasai, Tomonari, Seno, Masaharu
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press 2018
Fag:
Original article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054593/
https://ncbi.nlm.nih.gov/pubmed/29621663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2018.03.001
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