A Compartmentalized Type I Interferon Response in the Gut During Chronic HIV-1 Infection is Associated with Immunopathogenesis

OBJECTIVE(S): Type I IFN (IFN-I) responses confer both protective and pathogenic effects in persistent virus infections. IFN-I diversity, stage of infection and tissue compartment may account for this dichotomy. The gut is a major site of early HIV-1 replication and microbial translocation, but the...

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Publicado no:AIDS
Main Authors: DILLON, Stephanie M., GUO, Kejun, AUSTIN, Gregory L., GIANELLA, Sara, ENGEN, Phillip A, MUTLU, Ece A., LOSURDO, John, SWANSON, Garth, CHAKRADEO, Prachi, KESHAVARZIAN, Ali, LANDAY, Alan L., SANTIAGO, Mario L., WILSON, Cara C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054446/
https://ncbi.nlm.nih.gov/pubmed/29762170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000001863
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