THE RECEPTOR TGR5 MEDIATES THE PROKINETIC ACTIONS OF INTESTINAL BILE ACIDS AND IS REQUIRED FOR NORMAL DEFECATION IN MICE

BACKGROUND & AIMS: Abnormal delivery of bile acids (BAs) to the colon, due to disease or therapy, causes constipation or diarrhea by unknown mechanisms. The G protein-coupled BA receptor TGR5 (or GPBAR1) is expressed by enteric neurons and endocrine cells, which regulate motility and secretion....

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Publicat a:Gastroenterology
Autors principals: Alemi, Farzad, Poole, Daniel P., Chiu, Jonathan, Schoonjans, Kristina, Cattaruzza, Fiore, Grider, John R., Bunnett, Nigel W., Corvera, Carlos U.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054127/
https://ncbi.nlm.nih.gov/pubmed/23041323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2012.09.055
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