Hypomorphic Rag1 mutations alter the preimmune repertoire at early stages of lymphoid development

Hypomorphic RAG1 mutations allowing residual T- and B-cell development have been found in patients presenting with delayed-onset combined immune deficiency with granulomas and/or autoimmunity (CID-G/AI) and abnormalities of the peripheral T- and B-cell repertoire. To examine how hypomorphic Rag1 mut...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Ott de Bruin, L. M., Bosticardo, M., Barbieri, A., Lin, S. G., Rowe, J. H., Poliani, P. L., Ching, K., Eriksson, D., Landegren, N., Kämpe, O., Manis, J. P., Notarangelo, L. D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2018
Konular:
Immunobiology and Immunotherapy
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053949/
https://ncbi.nlm.nih.gov/pubmed/29743177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-12-820985
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