Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX models

PURPOSE: Pediatric glioblastoma (pGBM) is highly aggressive tumor in need of novel therapies. Our objective was to demonstrate the therapeutic efficacy of MLN8237 (Alisertib), an orally available selective inhibitor of Aurora A kinase (AURKA), and to evaluate which in vitro model system (monolayer o...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Kogiso, Mari, Qi, Lin, Braun, Frank K., Injac, Sarah G., Zhang, Linna, Du, Yuchen, Zhang, Huiyuan, Lin, Frank Y., Zhao, Sibo, Lindsay, Holly, Su, Jack, Baxter, Patricia, Adekunle, Adesina, Liao, Debra, Qian, Mark G., Berg, Stacey, Muscal, Jodi A., Li, Xiao-Nan
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052861/
https://ncbi.nlm.nih.gov/pubmed/29463553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2256
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados