Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7

Metformin, an FDA‐approved antidiabetic drug, has been shown to elongate lifespan in animal models. Nevertheless, the effects of metformin on human cells remain unclear. Here, we show that low‐dose metformin treatment extends the lifespan of human diploid fibroblasts and mesenchymal stem cells. We r...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Fang, Jingqi, Yang, Jiping, Wu, Xun, Zhang, Gangming, Li, Tao, Wang, Xi'e, Zhang, Hong, Wang, Chih‐chen, Liu, Guang‐Hui, Wang, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052468/
https://ncbi.nlm.nih.gov/pubmed/29659168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12765
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