Selective inhibition of carbonic anhydrase-IX by sulphonamide derivatives induces pH and reactive oxygen species-mediated apoptosis in cervical cancer HeLa cells

Selective inhibition with sulphonamides of carbonic anhydrase (CA) IX reduces cell proliferation and induces apoptosis in human cancer cells. The effect on CA IX expression of seven previously synthesised sulphonamide inhibitors, with high affinity for CA IX, as well as their effect on the prolifera...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Koyuncu, Ismail, Gonel, Ataman, Kocyigit, Abdurrahim, Temiz, Ebru, Durgun, Mustafa, Supuran, Claudiu T.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052416/
https://ncbi.nlm.nih.gov/pubmed/30001631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1481403
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