Increasing Enzyme Stability and Activity through Hydrogen Bond-Enhanced Halogen Bonds

[Image: see text] The construction of more stable proteins is important in biomolecular engineering, particularly in the design of biologics-based therapeutics. We show here that replacing the tyrosine at position 18 (Y18) of T4 lysozyme with the unnatural amino acid m-chlorotyrosine ((mCl)Y) increa...

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Udgivet i:Biochemistry
Main Authors: Carlsson, Anna-Carin C., Scholfield, Matthew R., Rowe, Rhianon K., Ford, Melissa Coates, Alexander, Austin T., Mehl, Ryan A., Ho, P. Shing
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052408/
https://ncbi.nlm.nih.gov/pubmed/29921126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00603
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