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Increasing Enzyme Stability and Activity through Hydrogen Bond-Enhanced Halogen Bonds
[Image: see text] The construction of more stable proteins is important in biomolecular engineering, particularly in the design of biologics-based therapeutics. We show here that replacing the tyrosine at position 18 (Y18) of T4 lysozyme with the unnatural amino acid m-chlorotyrosine ((mCl)Y) increa...
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| Publicado no: | Biochemistry |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2018
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6052408/ https://ncbi.nlm.nih.gov/pubmed/29921126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00603 |
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