Overexpression of CYB5R3 and NQO1, two NAD (+)‐producing enzymes, mimics aspects of caloric restriction

Calorie restriction (CR) is one of the most robust means to improve health and survival in model organisms. CR imposes a metabolic program that leads to increased stress resistance and delayed onset of chronic diseases, including cancer. In rodents, CR induces the upregulation of two NADH‐dehydrogen...

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Vydáno v:Aging Cell
Hlavní autoři: Diaz‐Ruiz, Alberto, Lanasa, Michael, Garcia, Joseph, Mora, Hector, Fan, Frances, Martin‐Montalvo, Alejandro, Di Francesco, Andrea, Calvo‐Rubio, Miguel, Salvador‐Pascual, Andrea, Aon, Miguel A., Fishbein, Kenneth W., Pearson, Kevin J., Villalba, Jose Manuel, Navas, Placido, Bernier, Michel, de Cabo, Rafael
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052403/
https://ncbi.nlm.nih.gov/pubmed/29706024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12767
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