Membrane-Bound CYB5R3 Is a Common Effector of Nutritional and Oxidative Stress Response Through FOXO3a and Nrf2

Aims: Membrane-bound CYB5R3 deficiency in humans causes recessive hereditary methaemoglobinaemia (RHM), an incurable disease that is characterized by severe neurological disorders. CYB5R3 encodes for NADH-dependent redox enzyme that contributes to metabolic homeostasis and stress protection; however...

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Detalhes bibliográficos
Main Authors: Siendones, Emilio, SantaCruz-Calvo, Sara, Martín-Montalvo, Alejandro, Cascajo, María V., Ariza, Julia, López-Lluch, Guillermo, Villalba, José M., Acquaviva-Bourdain, Cécile, Roze, Emmanuel, Bernier, Michel, de Cabo, Rafael, Navas, Plácido
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186635/
https://ncbi.nlm.nih.gov/pubmed/24450884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5479
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