RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease

The U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and other RNA-binding proteins (RBPs) are mislocalized to cytoplasmic neurofibrillary Tau aggregates in Alzheimer's disease (AD), yet the co-aggregation mechanisms are incompletely understood. U1-70K harbors two disordered low–complexity do...

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Vydáno v:J Biol Chem
Hlavní autoři: Bishof, Isaac, Dammer, Eric B., Duong, Duc M., Kundinger, Sean R., Gearing, Marla, Lah, James J., Levey, Allan I., Seyfried, Nicholas T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052236/
https://ncbi.nlm.nih.gov/pubmed/29802200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001747
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