The stimulatory G protein G(s)α is required in melanocortin 4 receptor–expressing cells for normal energy balance, thermogenesis, and glucose metabolism

Central melanocortin 4 receptors (MC4Rs) stimulate energy expenditure and inhibit food intake. MC4Rs activate the G protein G(s)α, but whether G(s)α mediates all MC4R actions has not been established. Individuals with Albright hereditary osteodystrophy (AHO), who have heterozygous G(s)α-inactivating...

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Vydáno v:J Biol Chem
Hlavní autoři: Podyma, Brandon, Sun, Hui, Wilson, Eric A., Carlson, Bradley, Pritikin, Ethan, Gavrilova, Oksana, Weinstein, Lee S., Chen, Min
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052205/
https://ncbi.nlm.nih.gov/pubmed/29794140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003450
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