mTORC1 Activation by Loss of Tsc1 in Myelinating Glia Causes Downregulation of Quaking and Neurofascin 155 Leading to Paranodal Domain Disorganization

Mutations in human tuberous sclerosis complex (TSC) genes TSC1 and TSC2 are the leading causes of developmental brain abnormalities and large tumors in other tissues. Murine Tsc1/2 have been shown to negatively regulate the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway in most t...

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Vydáno v:Front Cell Neurosci
Hlavní autoři: Shi, Qian, Saifetiarova, Julia, Taylor, Anna Marie, Bhat, Manzoor A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052123/
https://ncbi.nlm.nih.gov/pubmed/30050412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00201
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