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Endocrine cell type sorting and mature architecture in the islets of Langerhans require expression of Roundabout receptors in β cells

Pancreatic islets of Langerhans display characteristic spatial architecture of their endocrine cell types. This architecture is critical for cell-cell communication and coordinated hormone secretion. Islet architecture is disrupted in type-2 diabetes. Moreover, the generation of architecturally corr...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Adams, Melissa T., Gilbert, Jennifer M., Hinojosa Paiz, Jesus, Bowman, Faith M., Blum, Barak
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052079/
https://ncbi.nlm.nih.gov/pubmed/30022126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29118-x
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