p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis

Overexpression of EZH2 in estrogen receptor negative (ER-) breast cancer promotes metastasis. EZH2 has been mainly studied as the catalytic component of the Polycomb Repressive Complex 2 (PRC2) that mediates gene repression by trimethylating histone H3 at lysine 27 (H3K27me3). However, how EZH2 driv...

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Published in:Nat Commun
Main Authors: Anwar, Talha, Arellano-Garcia, Caroline, Ropa, James, Chen, Yu-Chih, Kim, Hong Sun, Yoon, Euisik, Grigsby, Sierrah, Basrur, Venkatesha, Nesvizhskii, Alexey I., Muntean, Andrew, Gonzalez, Maria E., Kidwell, Kelley M., Nikolovska-Coleska, Zaneta, Kleer, Celina G.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6051995/
https://ncbi.nlm.nih.gov/pubmed/30022044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05078-8
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