External Ion Access in the Na/K Pump: Kinetics of Na(+), K(+), and Quaternary Amine Interaction

Na/K pumps build essential ion gradients across the plasmalemma of animal cells by coupling the extrusion of three Na(+), with the import of two K(+) and the hydrolysis of one ATP molecule. The mechanisms of selectivity and competition between Na(+), K(+), and inhibitory amines remain unclear. We me...

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Bibliographische Detailangaben
Veröffentlicht in:Biophys J
Hauptverfasser: Stanley, Kevin S., Young, Victoria C., Gatto, Craig, Artigas, Pablo
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2018
Schlagworte:
Channels and Transporters
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6051257/
https://ncbi.nlm.nih.gov/pubmed/30021111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.06.007
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