Epigenetic silencing of miR‐1271 enhances MEK1 and TEAD4 expression in gastric cancer

Epigenetic dysregulation is a major driver of tumorigenesis. To identify tumor‐suppressive microRNAs repressed by DNA methylation in gastric cancer (GC), we analyzed the genome‐wide DNA methylation and microRNA expression profiles of EpCAM+/CD44+ GC cells. Among the set of microRNAs screened, miR‐12...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Lim, Byungho, Kim, Hee‐Jin, Heo, Haejeong, Huh, Nanhyung, Baek, Su‐Jin, Kim, Jong‐Hwan, Bae, Dong‐Hyuck, Seo, Eun‐Hye, Lee, Sang‐Il, Song, Kyu‐Sang, Kim, Seon‐Young, Kim, Yong Sung, Kim, Mirang
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6051202/
https://ncbi.nlm.nih.gov/pubmed/29862663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1605
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