MUC1‐C drives myeloid leukaemogenesis and resistance to treatment by a survivin‐mediated mechanism

Acute myeloid leukaemia (AML) is an aggressive haematological malignancy with an unmet need for improved therapies. Responses to standard cytotoxic therapy in AML are often transient because of the emergence of chemotherapy‐resistant disease. The MUC1‐C oncoprotein governs critical pathways of tumor...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Stroopinsky, Dina, Rajabi, Hasan, Nahas, Myrna, Rosenblatt, Jacalyn, Rahimian, Maryam, Pyzer, Athalia, Tagde, Ashujit, Kharbanda, Akriti, Jain, Salvia, Kufe, Turner, Leaf, Rebecca K., Anastasiadou, Eleni, Bar‐Natan, Michal, Orr, Shira, Coll, Maxwell D., Palmer, Kristen, Ephraim, Adam, Cole, Leandra, Washington, Abigail, Kufe, Donald, Avigan, David
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050463/
https://ncbi.nlm.nih.gov/pubmed/29761849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13662
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