Global Effects of DDX3 Inhibition on Cell Cycle Regulation Identified by a Combined Phosphoproteomics and Single Cell Tracking Approach

DDX3 is an RNA helicase with oncogenic properties. The small molecule inhibitor RK-33 is designed to fit into the ATP binding cleft of DDX3 and hereby block its activity. RK-33 has shown potent activity in preclinical cancer models. However, the mechanism behind the antineoplastic activity of RK-33...

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Dettagli Bibliografici
Pubblicato in:Transl Oncol
Autori principali: Heerma van Voss, Marise R., Kammers, Kai, Vesuna, Farhad, Brilliant, Justin, Bergman, Yehudit, Tantravedi, Saritha, Wu, Xinyan, Cole, Robert N., Holland, Andrew, van Diest, Paul J., Raman, Venu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press 2018
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Original article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050443/
https://ncbi.nlm.nih.gov/pubmed/29684792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2018.04.001
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