Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment

DDX3 is a DEAD box RNA helicase with oncogenic properties. RK-33 is developed as a small molecule inhibitor of DDX3 and showed potent radiosensitizing activity in preclinical tumor models. This study aimed to assess DDX3 as a target in breast cancer and to elucidate how RK-33 exerts its anti-neoplas...

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Détails bibliographiques
Publié dans:Oncogene
Auteurs principaux: Heerma van Voss, Marise R., Vesuna, Farhad, Bol, Guus M., Afzal, Junaid, Tantravedi, Saritha, Bergman, Yehudit, Kammers, Kai, Lehar, Mohamed, Malek, Reem, Ballew, Matthew, ter Hoeve, Natalie, Abou, Diane, Thorek, Daniel, Berlinicke, Cynthia, Yazdankhah, Meysam, Sinha, Debasish, Le, Anne, Abrahams, Roselle, Tran, Phuoc T., van Diest, Paul J., Raman, Venu
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756132/
https://ncbi.nlm.nih.gov/pubmed/28869602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.308
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