Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment

DDX3 is a DEAD box RNA helicase with oncogenic properties. RK-33 is developed as a small molecule inhibitor of DDX3 and showed potent radiosensitizing activity in preclinical tumor models. This study aimed to assess DDX3 as a target in breast cancer and to elucidate how RK-33 exerts its anti-neoplas...

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Vydáno v:Oncogene
Hlavní autoři: Heerma van Voss, Marise R., Vesuna, Farhad, Bol, Guus M., Afzal, Junaid, Tantravedi, Saritha, Bergman, Yehudit, Kammers, Kai, Lehar, Mohamed, Malek, Reem, Ballew, Matthew, ter Hoeve, Natalie, Abou, Diane, Thorek, Daniel, Berlinicke, Cynthia, Yazdankhah, Meysam, Sinha, Debasish, Le, Anne, Abrahams, Roselle, Tran, Phuoc T., van Diest, Paul J., Raman, Venu
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756132/
https://ncbi.nlm.nih.gov/pubmed/28869602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.308
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